Xue Zhigang
Xue Zhigang Professor
Professor, Stem Cell Research Center, Department of Regenerative Medicine, Tongji University
Chief Technology Officer, Source Bio
Diving into the heart and mind, sharpening the body and mind!
Single-cell RNA sequencing technology was used to reveal the genetic program of human and mouse early embryos, and the research results were published in the journal Nature, which is the first time for Chinese scientists to publish such articles in the journal. This research result will have far-reaching impact in the field of purification, classification and clinical treatment of stem cells.
● Professor and Doctoral Supervisor, Stem Cell Research Center, Department of Regenerative Medicine, Tongji University and Stem Cell Clinical Translation Center, Tongji Hospital
● Top domestic innovative B talents introduced by Hunan Province, national industry leading talents
● Chief Technology Officer of Yuanpin Bio
Presided over 3 projects of National Natural Science Foundation of China and participated in National Key Research and Development Program as a sub-topic leader; published more than 20 SCI papers, with the highest number of citations of a single paper reaching more than 270; applied for many patents; won the second prize of National Science and Technology Progress Award, the first prize of Natural Science of Maternal and Child Health Science and Technology Award, the first prize of Shanghai Medical Science and Technology, the first prize of Shanghai Science and Technology Progress, and the Science and Technology Prize of Jiangsu Province, and other various awards. Award.
Single-cell sequencing technology.
The dawn of a new era!
Single-cell genomics aims to study individual cells through histological methods. This young field has been rapidly maturing in recent years with technological advances, and in July 2012, Nature Biotechnology published the landmark single-cell sequencing method, Smart-Seq, which is capable of generating full-length cDNAs covering the entire transcriptome. full-length cDNA, and even now, there are few single-cell sequencing solutions that can do this.
In May 2016, Prof. Zhigang Xue's team published their own developed sequencing technology, scMT-seq, in the journal Genome Biology. this method is able to analyze both the transcriptome and methylome of a cell simultaneously, revealing the direct correlation between DNA methylation and gene expression in a single cell. Using this technology, we have further completed the analysis of the correlation between the inactivation of X chromosome and infertility in different developmental periods of human and crab-eating monkey early embryos, and these results will help to reduce the occurrence of abnormal embryonic pregnancies and other phenomena.
Mesenchymal stem cells for the treatment of neococcal pneumonia.
Major scientific discoveries are born one after another!
At the beginning of 2020, when the epidemic of neococcal pneumonia broke out, Prof. Xue Zhigang led the scientific research team of Yuanpin Biologicals, and went all out to carry out scientific research, and made a series of major technological breakthroughs in just ten days, and conducted in-depth research and discussions with clinicians who were in the front line of clinical treatment of patients at the cooperative hospitals, such as the No. 2 Hospital of Xiangya of Central South University, the No. 3 Hospital of Xiangya of Central South University, the No. 2 Hospital of the Second Annex of Nanhua University, and the No. 2 Hospital of Nanhua University. In-depth research and discussion, and finally formed a more scientific stem cell treatment of new coronary pneumonia clinical research program, “umbilical cord mesenchymal stem cells for the treatment of new coronary virus pneumonia key technology research and clinical application demonstration” research project, won the Hunan Provincial Science and Technology Department of the project, Hunan Province, one of the first batch of emergency special projects to fight against the new coronary pneumonia epidemic.
The clinical research program for the treatment of neocoronavirus pneumonia integrates the specialties of infection, chest, respiratory, cell biology and molecular biology, and formulates a set of scientific, reasonable, safe and effective clinical application program, including the design of the treatment course, the way of administration, the method of operation, the type of drug to be administered, the dosage, the main ingredients, the indications, the contraindications, the disposition of emergencies, and the evaluation of the effectiveness of the content and standards. Application program. We have customized personalized treatment strategies in three aspects: prevention of new coronary pneumonia, preventing the transformation of patients with mild to moderate illnesses to severe illnesses, increasing the rescue rate of patients with severe and critical illnesses, and reducing the mortality rate.
In the process of scientific research In the process of scientific research, the scientific research team has made breakthrough discoveries in the mechanism and mechanism of action of stem cell therapy for neocoronaryngitis by adopting the unique single-cell subpopulation fractal and high-throughput sequencing technology, laying a solid foundation for the development of future stem cell drugs and technologies. The company has applied for 5 related international invention patents and 16 domestic invention patents, and 3 heavyweight research papers will be published in top international medical journals.
Preaching and teaching, not forgetting the beginning!
▲ Prof. Zhigang Xue was invited to give a keynote speech at the First Xingsha Overseas High-level Talents Innovation and Entrepreneurship Forum
▲ Prof. Zhigang Xue was invited to attend the first Huxiang Maternity Health Summit to explain the clinical progress of neonatal stem cells.
▲ Prof. Zhigang Xue was invited to give a lecture on the progress and application of stem cell technology.
Research Projects and Talent Programs
| Research Projects | Research Project | No. | Time | Progress | Participation |
| National Key R&D Program | Cellular Programming in Human Embryonic Development and Mechanisms of Gamete/Embryo-Origin Diseases - (Processes and Mechanisms of Cellular Programming and Reprogramming in Early Human Embryonic Development) | 2017YFC1001301 | 2017.07-2020.12 | Research in progress | Chair |
| National Natural Science Foundation of China | Mechanism of PGC-1α signaling pathway affecting nematode replication and activation in human blocked embryos | 81771651 | 2018.01-2021.12 | In Progress | Under the auspices of |
| National Key R&D Program | Basic Research on Establishment and Application of Assisted Reproduction Population and Offspring Cohort in Chinese Population - (Research on the Influence of Pregnancy Factors on Offspring Health and Mechanisms) | 2016YFC1000208 | 2016.07-2021.06 | Research in progress | Participation |
| Project of Shanghai Science and Technology Commission in the field of basic research | Mechanism of infertility triggered by imbalance of metabolic regulatory network during mitochondrial activation in preimplantation embryos | 16JC1404700 | 2016.07-2019.06 | Completed | Chair |
| Tongji University, “Special Funds for Basic Research Operating Costs of Central Universities” Program | Research on the mechanism of mitochondrial replication and activation in early human embryos based on PGC-1α signaling pathway. | 2016.01-2017.12 | Completed | Chair | |
| Shanghai Tongji Biomedical Technology Co. | Translational Application of Human Umbilical Cord Mesenchymal Stem Cells in the Clinical Treatment of Premature Ovarian Failure. | 2015.10-2017.10 | Completed | Chair | |
| National Natural Science Foundation of China | Research on the molecular mechanism of the correlation between X chromosome inactivation and abnormal embryonic development | 81430026 | 2015.01-2019.12 | Completed | Chair |
| Science and Technology Program of Jiangsu Provincial Science and Technology Department | Research and Development of ASEAN Reproductive Medical Product Technology in China (Guangxi) | BM2014052 | 2014.07-2016.12 | Completed | Hosted by |
| Shanghai Dawning Program | Epigenetic regulation during early human embryonic development | 13SG22 | 2014.01-2016.12 | Completed | Under the auspices of |
| Shanghai Municipal Health and Family Planning Commission | Screening of cell-standardized molecular markers in stem cell therapy for spinal cord injury | XBR2013094 | 2014.01-2017.01 | Completed | Participation |
| National Natural Science Foundation of China | Mechanism study and drug screening of neurodevelopmental abnormalities based on the Fragile X chromosome syndrome iPSC cell model | 81271258 | 2013.01-2013.12 | Completed | Chair |
| 973 Subjects | Functional and region-specific neuronal and gliogenic regulatory network research | 2012CB966303 | 2012.01-2016.12 | Completed | Participation |
| Natural Science Foundation of Jiangsu Province | Experimental study of human iPSC-RPE transplantation for the treatment of age-related macular degeneration | DK2011321 | 2011.07-2014.07 | Completed | Chair |
| 973 Subjects | Regulatory network and intervention strategy of tissue stem cells in organ aging and regeneration | 2011CB966204 | 2011.01-2015.12 | Completed | Participation |
| International Cooperation Program of Ministry of Science and Technology | Basic and preclinical research on stem cell therapy and product development | 2011DFB30010 | 2011.01-2013.12 | Completed | Participation |
| National Natural Science Foundation of China | Construction of enhanced tumor-specific killing vector and its functional study | 30500302 | 2006.01-2008.12 | Completed | Chairperson |
Awards
1. In 2015, the research project “Basic research and application of environmental and genetic factors on male reproductive function” won the Second Prize of the State Council National Science and Technology Progress Award;
2. In 2015, “Research on the genetic mechanism of common hereditary diseases”, First Prize of Natural Science Award, Maternal and Child Health Research Association, Maternal and Child Health Science and Technology Award;
3.In 2014, the research project “Biomechanics and Biology of Spinal Cord Injury Repair and Reconstruction and Clinical Application” was awarded the First Prize of Shanghai Science and Technology Progress Award by Shanghai Municipal People's Government;
4. In 2014, the research project “Influence of environmental and genetic factors on male reproductive function” was awarded the First Prize of Jiangsu Science and Technology Award by Jiangsu Provincial Science and Technology Department;
5.In 2013, the research project “Clinical and related basic research on repair and reconstruction of spinal cord injury” won the first prize of Shanghai Medical Science and Technology Award of Shanghai Medical Association.
